Comparative and evolutionary analyses of the divergence of plant oligosaccharyltransferase STT3 isoforms.

ABSTRACT: STT3 is a catalytic subunit of hetero-oligomeric oligosaccharyltransferase (OST), which is important for asparagine-linked glycosylation. In mammals and plants, OSTs with different STT3 isoforms exhibit distinct levels of enzymatic efficiency or different responses to stressors. Although two different STT3 isoforms have been identified in both plants and animals, it remains unclear whether these isoforms result from gene duplication in an ancestral eukaryote. Furthermore, the molecular mechanisms underlying the functional divergences between the two STT3 isoforms in plant have not been well elucidated. Here, we conducted phylogenetic analysis of the major evolutionary node species and suggested that gene duplications of STT3 may have occurred independently in animals and plants. Across lan

SUBMITTER: Niu G 

PROVIDER: S-EPMC7050244 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature