Neonatal BCG vaccination and child survival in TB-exposed and TB-unexposed children: a prospective cohort study.

ABSTRACT:

Objectives

To assess the association between neonatal BCG vaccination and mortality between 28 days and 3 years of age among tuberculosis (TB)-exposed and TB-unexposed children.

Design

Prospective cohort study.

Setting

Bandim Health Project runs an urban Health and Demographic Surveillance site in Guinea-Bissau with registration of mortality, vaccination status and TB cases.

Participants

Children entered the analysis when their vaccination card was inspected after 28 days of age and remained under surveillance to 3 years of age. Children residing in the same house as a TB case were classified as TB-exposed from 3 months prior to case registration to the end of follow-up.

Methods

Using Cox-proportional hazards models with age as underlying time scale, we

SUBMITTER: Thysen SM 

PROVIDER: S-EPMC7050365 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature