Early cardiac dysfunction in children and young adults with perinatally acquired HIV.

ABSTRACT:

Objective

To define the prevalence of early cardiac dysfunction in children and young adults with perinatally acquired HIV and predictors of cardiac function.

Design

Cross-sectional design.

Methods

Early cardiac dysfunction was defined as left ventricular (LV) global longitudinal strain z-score less than -2 or myocardial performance index at least 0.5 with normal LV ejection fraction. Regression models were fitted to assess the relationship between measures of cardiac function and HIV RNA levels, clinical variables, and markers of inflammation.

Results

Six hundred and forty-three individuals (mean age 14.1 ± 5.2 years) were enrolled. The average time on combination antiretroviral treatment was 6.8 ± 3.6 years. Nearly 28% of individuals met criteria for early ca

SUBMITTER: McCrary AW 

PROVIDER: S-EPMC7050370 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature