Effects of working memory training on cognitive, affective, and biological responses to stress in major depression: A novel cognitive bias modification protocol.

ABSTRACT:

Background

Over 320 million individuals are living with Major Depressive Disorder (MDD), a leading cause of disability worldwide. Thus, there is a crucial need to identify processes that contribute to the maintenance of depressive episodes. Difficulty removing negative information from working memory (WM) is posited to exacerbate affective, cognitive, and biological dysregulation in Major Depressive Disorder (MDD), but this has not yet been tested empirically.

Methods

In this study we examined whether training depressed individuals to remove negative information from WM (RNI training) would reduce symptoms of depression and levels of rumination, and would be associated with attenuated biological responsivity to stress. Individuals diagnosed with MDD were randomly assigned to

SUBMITTER: Jopling E 

PROVIDER: S-EPMC7050386 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature