Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent.

ABSTRACT: Hybrid molecules have been developed which are comprised of a tyrosine kinase-targeted, quinazoline-based scaffold and a flexibly linked dia(m)minechloridoPt(ii) moiety. The target compounds maintain high affinity and selectivity for ErbB family kinase proteins and one of the derivatives induces platinum adducts with a pharmacologically important cysteine residue.

SUBMITTER: Yang M 

PROVIDER: S-EPMC7050444 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature