Omp2b Porin Alteration in the Course of Evolution of Brucella spp.

ABSTRACT: The genus Brucella comprises major pathogenic species causing disease in livestock and humans, e.g. B. melitensis. In the past few years, the genus has been significantly expanded by the discovery of phylogenetically more distant lineages comprising strains from diverse wildlife animal species, including amphibians and fish. The strains represent several potential new species, with B. inopinata as solely named representative. Being genetically more distant between each other, relative to the "classical" Brucella species, they present distinct atypical phenotypes and surface antigens. Among surface protein antigens, the Omp2a and Omp2b porins display the highest diversity in the classical Brucella species. The genes coding for these proteins are closely linked in the Brucella genome and ori

SUBMITTER: Cloeckaert A 

PROVIDER: S-EPMC7050475 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature