Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance.

ABSTRACT: Imprinted genes are highly expressed in monoaminergic regions of the midbrain and their functions in this area are thought to have an impact on mammalian social behaviors. One such imprinted gene is Grb10, of which the paternal allele is generally recognized as mediating social dominance behavior. However, there has been no detailed study of social dominance in Grb10 ^+/p mice. Moreover, the original study examined tube-test behavior in isolated mice 10 months of age. Isolation testing favors more territorial and aggressive behaviors, and does not address social dominance strategies employed in group housing contexts. Furthermore, isolation stress impacts midbrain function and dominance related behavior, often through alterations in monoaminergic signaling. Thus, we undertook a s

SUBMITTER: Rienecker KDA 

PROVIDER: S-EPMC7050506 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature