Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC7050528 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Zhang Lei L He Anshun A Chen Bohan B Bi Jinfang J Chen Jun J Guo Dianhao D Qian Yuyang Y Wang Wenbin W Shi Tengfei T Zhao Zhongfang Z Shi Jiandang J An Woojin W Attenello Frank F Lu Wange W
Genome research 20200117 2
Temozolomide (TMZ) is a frequently used chemotherapy for glioma; however, chemoresistance is a major problem limiting its effectiveness. Thus, knowledge of mechanisms underlying this outcome could improve patient prognosis. Here, we report that deletion of a regulatory element in the <i>HOTAIR</i> locus increases glioma cell sensitivity to TMZ and alters transcription of multiple genes. Analysis of a combination of RNA-seq, Capture Hi-C, and patient survival data suggests that <i>CALCOCO1</i> an ...[more]