A comparison of gene expression and DNA methylation patterns across tissues and species.

ABSTRACT: Previously published comparative functional genomic data sets from primates using frozen tissue samples, including many data sets from our own group, were often collected and analyzed using nonoptimal study designs and analysis approaches. In addition, when samples from multiple tissues were studied in a comparative framework, individuals and tissues were confounded. We designed a multitissue comparative study of gene expression and DNA methylation in primates that minimizes confounding effects by using a balanced design with respect to species, tissues, and individuals. We also developed a comparative analysis pipeline that minimizes biases attributable to sequence divergence. Thus, we present the most comprehensive catalog of similarities and differences in gene expression and DNA methyl

SUBMITTER: Blake LE 

PROVIDER: S-EPMC7050529 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature