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The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia.

ABSTRACT: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and biological heterogeneity in this disease has already translated into new prognostic biomarkers, improved leukemia animal models, and emerging targeted therapies. This work reviews our current understanding of the molecular mechanisms of T-ALL.

SUBMITTER: Gianni F

PROVIDER: S-EPMC7050584 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia.

Gianni Francesca F Belver Laura L Ferrando Adolfo A

Cold Spring Harbor perspectives in medicine 20200302 3

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and biological heterogeneity in this disease has already translated into new prognostic biomarkers, improved leukemia animal models, and emerging targeted therapies. This work reviews our current understanding of the molecular mechanisms of T-ALL. ...[more]

PMID: 31570389

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