Designs of Antigen Structure and Composition for Improved Protein-Based Vaccine Efficacy.

ABSTRACT: Today, vaccinologists have come to understand that the hallmark of any protective immune response is the antigen. However, it is not the whole antigen that dictates the immune response, but rather the various parts comprising the whole that are capable of influencing immunogenicity. Protein-based antigens hold particular importance within this structural approach to understanding immunity because, though different molecules can serve as antigens, only proteins are capable of inducing both cellular and humoral immunity. This fact, coupled with the versatility and customizability of proteins when considering vaccine design applications, makes protein-based vaccines (PBVs) one of today's most promising technologies for artificially inducing immunity. In this review, we follow the development

SUBMITTER: Saylor K 

PROVIDER: S-EPMC7050619 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature