The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis.

ABSTRACT:

Background

Genetic studies of single gene variants have been criticized as providing a simplistic characterization of the genetic basis of illness risk that ignores the effects of other variants within the same biological pathways. Of candidate biological pathways for schizophrenia (SZ), the cell adhesion molecule (CAM) pathway has repeatedly been linked to both psychosis and neurocognitive dysfunction. Here we tested, using risk allele scores derived from the Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ), whether alleles within the CAM pathway were correlated with poorer neuropsychological function in patients.

Method

In total, 424 patients with psychosis were assessed in areas of cognitive ability typically found to be impaired in SZ: intelli

SUBMITTER: Hargreaves A 

PROVIDER: S-EPMC7050679 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature