Impact of vitamin D supplementation on C-reactive protein; a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

To evaluate the effect of vitamin D supplementation on C-reactive protein (CRP) through a systematic review and meta-analysis of randomized control trials (RCTs).

Methods

PubMed-Medline, SCOPUS, Google Scholar and Web of Science databases were searched (up until April 2016) to identify RCTs evaluating the impact of vitamin D supplementation on CRP. We used random effects models (using DerSimonian-Laird method) as well as the generic inverse variance methods for quantitative data synthesis. For sensitivity analysis, we applied leave-one-out approach. To examine the heterogeneity we used I2 index. Registration code: CRD42016036932.

Results

Among 1274 search items, 24 studies met the inclusion criteria in the final evaluation. Pooling the data together

SUBMITTER: Mazidi M 

PROVIDER: S-EPMC7050714 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature