Associations between recent thymic emigrants and CD4+ T-cell recovery after short-term antiretroviral therapy initiation.

ABSTRACT:

Objective

Around 20-30% of HIV-infected individuals (HIV+) on successful antiretroviral therapy (ART) fail to normalize their CD4 T-cell counts. Various factors could contribute to the lack of immune reconstitution, one of them being thymic insufficiency. We aimed to explore associations between recent thymic emigrants (RTEs) and CD4 T-cell recovery.

Design

ART-naive HIV+ individuals who started ART with advanced AIDS were selected. Good versus poor immune reconstitution was defined by CD4 gains above or below 100 CD4 T cells/μl. The follow-up period was 6 months.

Methods

Peripheral blood mononuclear cells were isolated and flow cytometry was used to characterize RTEs as the fraction of naive CD4 T cells expressing CD31, the platelet endothelial cell adhesion molecule

SUBMITTER: Briceno O 

PROVIDER: S-EPMC7050791 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature