CoA Synthase (COASY) Mediates Radiation Resistance via PI3K Signaling in Rectal Cancer.

ABSTRACT: Neoadjuvant radiation is standard of care for locally advanced rectal cancer. Response to radiation is highly variable and directly linked with survival. However, there currently are no validated biomarkers or molecular targets to predict or improve radiation response, which would help develop personalized treatment and ideally targeted therapies. Here, we identified a novel biomarker, coenzyme A synthase (COASY), whose mRNA expression was consistently elevated in radioresistant human rectal cancers. This observation was validated in independent patient cohorts and further confirmed in colorectal cancer cell lines. Importantly, genetic overexpression and knockdown yielded radioresistant and sensitive phenotypes, respectively, in vitro and in vivo. COASY-knockdown xenografts w

SUBMITTER: Ferrandon S 

PROVIDER: S-EPMC7050829 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature