Visible-Light-Activated High-Density Materials for Controlled in Vivo Insulin Release.

ABSTRACT: In this work, we describe the synthesis, characterization, and ultimate in vivo assessment of second-generation insulin photoactivated depot (PAD) materials. These are the first to use visible light to stimulate insulin release and have an in vivo performance that is 28-fold improved relative to first-generation materials. This improvement is due to two major factors linked to the utilized chemistry: (1) we have incorporated the coumarin photocleavable group, which increases the photorelease wavelength into the visible range, enhancing tissue penetration of the light; (2) phototoggling of insulin solubility is produced by linking three insulin molecules to a central bridge via light cleaved groups, and not by bonding to a large polymer. The resulting trimer is, therefore, highly dense (87%

SUBMITTER: Sarode BR 

PROVIDER: S-EPMC7050939 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature