White matter microstructure mediates the association between prenatal exposure to phthalates and behavior problems in preschool children.

ABSTRACT:

Background

Previous research reports associations between prenatal exposure to phthalates and childhood behavior problems; however, the neural mechanisms that may underlie these associations are relatively unexplored.

Objective

This study examined microstructural white matter as a possible mediator of the associations between prenatal phthalate exposure and behavior problems in preschool-aged children.

Methods

Data are from a subsample of a prospective pregnancy cohort, the Alberta Pregnancy Outcomes and Nutrition (APrON) study (n = 76). Mother-child pairs were included if mothers provided a second trimester urine sample, if the child completed a successful magnetic resonance imaging (MRI) scan at age 3-5 years, and if the Child Behavior Checklist was completed within

SUBMITTER: England-Mason G 

PROVIDER: S-EPMC7050961 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature