Maternal and child gluten intake and association with type 1 diabetes: The Norwegian Mother and Child Cohort Study.

ABSTRACT: BACKGROUND:The relationship between maternal gluten intake in pregnancy, offspring intake in childhood, and offspring risk of type 1 diabetes has not been examined jointly in any studies. Our aim was to study the relationship between maternal and child intake of gluten and risk of type 1 diabetes in children. METHODS AND FINDINGS:We included 86,306 children in an observational nationwide cohort study, the Norwegian Mother and Child Cohort Study (MoBa), with recruitment from 1999 to 2008 and with follow-up time to April 15, 2018. We used registration of type 1 diabetes in the Norwegian childhood diabetes registry as the outcome. We used Cox proportional hazard regression to estimate hazard ratios (HRs) for the mother's intake of gluten up to week 22 of pregnancy and offspring gluten intake

SUBMITTER: Lund-Blix NA 

PROVIDER: S-EPMC7051049 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature