Apolipoprotein E regulates the maturation of injury-induced adult-born hippocampal neurons following traumatic brain injury.

ABSTRACT: Various brain injuries lead to the activation of adult neural stem/progenitor cells in the mammalian hippocampus. Subsequent injury-induced neurogenesis appears to be essential for at least some aspects of the innate recovery in cognitive function observed following traumatic brain injury (TBI). It has previously been established that Apolipoprotein E (ApoE) plays a regulatory role in adult hippocampal neurogenesis, which is of particular interest as the presence of the human ApoE isoform ApoE4 leads to significant risk for the development of late-onset Alzheimer's disease, where impaired neurogenesis has been linked with disease progression. Moreover, genetically modified mice lacking ApoE or expressing the ApoE4 human isoform have been shown to impair adult hippocampal neurogenesis under

SUBMITTER: Tensaouti Y 

PROVIDER: S-EPMC7051085 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature