Is food type important for in vitro post ingestion bioaccessibility models of polychlorinated biphenyls sorbed to soil?

ABSTRACT: Soils are sorbents for many organic compounds and children consume relatively large amounts of soil. To improve the estimated health risks from this exposure pathway, we examined the role of co-ingested foods in determining the post-ingestion bioaccessibility (mobilization) of 18 polychlorinated biphenyls (PCBs) sorbed to 10 characterized soils. The bioaccessibility test system (DIN 19738, 2004) was an in vitro, 3-compartment, digestive tract containing salts, protein, and bile. Each soil was fortified with PCBs, then, digestive fluids appropriate to each compartment, were added sequentially. Next, digestive fluid and soil were seperated and PCB concentrations in both media were measured. This complete test system was then reduced to assess contributions of individual endogenous digestive

SUBMITTER: Starr JM 

PROVIDER: S-EPMC7051099 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature