CD11c⁺ B Cells Are Mainly Memory Cells, Precursors of Antibody Secreting Cells in Healthy Donors.

ABSTRACT: CD11c⁺ B cells have been reported to be increased in autoimmune diseases, but they are detected in the blood of healthy individuals as well. We aimed to characterize CD11c⁺ B cells from healthy donors by flow cytometry, microarray analysis, and in vitro functional assays. Here, we report that CD11c⁺ B cells are a distinct subpopulation of B cells, enriched in the memory subpopulation even if their phenotype is heterogeneous, with overexpression of genes involved in B-cell activation and differentiation as well as in antigen presentation. Upon activation, CD11c⁺ B cells can differentiate into antibody-secreting cells, and CD11c could be upregulated in CD11c^- B cells by B-cell receptor activation. Finally, we show that patients wi

SUBMITTER: Golinski ML 

PROVIDER: S-EPMC7051942 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature