Deep Evolutionary History of the Phox and Bem1 (PB1) Domain Across Eukaryotes.

ABSTRACT: Protein oligomerization is a fundamental process to build complex functional modules. Domains that facilitate the oligomerization process are diverse and widespread in nature across all kingdoms of life. One such domain is the Phox and Bem1 (PB1) domain, which is functionally well-studied in the animal kingdom. However, beyond animals, neither the origin nor the evolutionary patterns of PB1-containing proteins are understood. While PB1 domain proteins have been found in other kingdoms including plants, it is unclear how these relate to animal PB1 proteins. To address this question, we utilized large transcriptome datasets along with the proteomes of a broad range of species. We discovered eight PB1 domain-containing protein families in plants, along with four each in Protozoa and Fungi and

SUBMITTER: Mutte SK 

PROVIDER: S-EPMC7051960 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature