PET imaging of medulloblastoma with an ¹⁸F-labeled tryptophan analogue in a transgenic mouse model.

ABSTRACT: In vivo positron emission tomography (PET) imaging is a key modality to evaluate disease status of brain tumors. In recent years, tremendous efforts have been made in developing PET imaging methods for pediatric brain tumors. Carbon-11 labelled tryptophan derivatives are feasible as PET imaging probes in brain tumor patients with activation of the kynurenine pathway, but the short half-life of carbon-11 limits its application. Using a transgenic mouse model for the sonic hedgehog (Shh) subgroup of medulloblastoma, here we evaluated the potential of the newly developed 1-(2-[¹⁸F]fluoroethyl)-L-tryptophan (1-L-[¹⁸F]FETrp) as a PET imaging probe for this common malignant pediatric brain tumor. 1-L-[¹⁸F]FETrp was synthesized on a PETCHEM automatic synthesizer w

SUBMITTER: Xin Y 

PROVIDER: S-EPMC7051973 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature