The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: an intergenerational approach.

ABSTRACT: While biological alterations associated with childhood maltreatment (CM) have been found in affected individuals, it remains unknown to what degree these alterations are biologically transmitted to the next generation. We investigated intergenerational effects of maternal CM on DNA methylation and gene expression in N = 113 mother-infant dyads shortly after parturition, additionally accounting for the role of the FKBP5 rs1360780 genotype. Using mass array spectrometry, we assessed the DNA methylation of selected stress-response-associated genes (FK506 binding protein 51 [FKBP5], glucocorticoid receptor [NR3C1], corticotropin-releasing hormone receptor 1 [CRHR1]) in isolated immune cells from maternal blood and neonatal umbilical cord blood. In mothers, CM was associated with decreased leve

SUBMITTER: Ramo-Fernandez L 

PROVIDER: S-EPMC7052131 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature