Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC7052134 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Li Saiyang S Huang Chi C Hu Guanghui G Ma Junjie J Chen Yonghui Y Zhang Jin J Huang Yiran Y Zheng Junhua J Xue Wei W Xu Yunfei Y Zhai Wei W
Cell death & disease 20200302 3
While B cells in the tumor microenvironment (TME) might play important roles in cancer progression, their impacts on the renal cell carcinoma (RCC) metastasis remained unclear, which drew our attention to further explore. We found that RCC tissues could recruit more B cells than the surrounding normal renal tissues from human clinical RCC samples. Wound healing assay, transwell assay and 3D invasion assays demonstrated that recruited B cells, also known as tumor-educated B cells (TEB), could sig ...[more]