Metabolic response patterns in brain microdialysis fluids and serum during interstitial cisplatin treatment of high-grade glioma.

ABSTRACT:

Background

High-grade gliomas are associated with poor prognosis. Tumour heterogeneity and invasiveness create challenges for effective treatment and use of systemically administrated drugs. Furthermore, lack of functional predictive response-assays based on drug efficacy complicates evaluation of early treatment responses.

Methods

We used microdialysis to deliver cisplatin into the tumour and to monitor levels of metabolic compounds present in the tumour and non-malignant brain tissue adjacent to tumour, before and during treatment. In parallel, we collected serum samples and used multivariate statistics to analyse the metabolic effects.

Results

We found distinct metabolic patterns in the extracellular fluids from tumour compared to non-malignant brain tissue, includ

SUBMITTER: Bjorkblom B 

PROVIDER: S-EPMC7052137 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature