Enzymatic decontamination of paraoxon-ethyl limits long-term effects in planarians.

ABSTRACT: Organophosphorus compounds (OP) are highly toxic molecules used as insecticides that inhibit cholinesterase enzymes involved in neuronal transmission. The intensive use of OP for vector control and agriculture has led to environmental pollutions responsible for severe intoxications and putative long-term effects on humans and wild animals. Many in vivo models were studied over the years to assess OP acute toxicity, but the long-term effects are poorly documented. Planarian, a freshwater flatworm having a cholinergic system, has emerged as a new original model for addressing both toxicity and developmental perturbations. We used Schmidtea mediterranea planarians to evaluate long-term effects of paraoxon-ethyl at two sublethal concentrations over three generations. Toxicity, developmental pe

SUBMITTER: Poirier L 

PROVIDER: S-EPMC7052158 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature