Gap Junction Coding Innexin in Lymnaea stagnalis: Sequence Analysis and Characterization in Tissues and the Central Nervous System.

ABSTRACT: Connections between neurons called synapses are the key components underlying all nervous system functions of animals and humans. However, important genetic information on the formation and plasticity of one type, the electrical (gap junction-mediated) synapse, is understudied in many invertebrates. In the present study, we set forth to identify and characterize the gap junction-encoding gene innexin in the central nervous system (CNS) of the mollusk pond snail Lymnaea stagnalis. With PCR, 3' and 5' RACE, and BLAST searches, we identified eight innexin genes in the L. stagnalis genome, named Lst Inx1-Lst Inx8. Phylogenetic analysis revealed that the L. stagnalis innexin genes originated from a single copy in the common ancestor of molluskan species by multiple g

SUBMITTER: Mersman BA 

PROVIDER: S-EPMC7052179 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature