Structure-Function Studies and Mechanism of Action of Snake Venom L-Amino Acid Oxidases.

ABSTRACT: Snake venom L-amino acid oxidases (SV-LAAOs) are the least studied venom enzymes. These enzymes catalyze the stereospecific oxidation of an L-amino acid to their corresponding α-keto acid with the liberation of hydrogen peroxide (H₂O₂) and ammonia (NH₃). They display various pathological and physiological activities including induction of apoptosis, edema, platelet aggregation/inhibition, hemorrhagic, and anticoagulant activities. They also show antibacterial, antiviral and leishmanicidal activity and have been used as therapeutic agents in some disease conditions like cancer and anti-HIV drugs. Although the crystal structures of six SV-LAAOs are present in the Protein Data Bank (PDB), there is no single article that describes all of them in particular. To

SUBMITTER: Ullah A 

PROVIDER: S-EPMC7052187 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature