Primed macrophages directly and specifically reject allografts.

ABSTRACT: Monocytes and macrophages have long been associated with acute and chronic allograft rejection; this is mediated by their abilities to promote inflammation, kill target cells via antibody-dependent cytotoxicity and modulate adaptive immunity. Our present study showed that allogeneic antigen-primed macrophages acutely rejected skin grafts with specificity after adoptive transfer into MHC-matched immunodeficient mice. The ability of primed macrophages to reject allografts essentially requires the help of CD4⁺ T cells and does not require the help of CD8⁺ T cells. Moreover, the primed, perforin-deficient macrophages rejected the skin grafts in a significantly delayed pattern compared with WT macrophages, indicating that the perforin pathway of the primed macrophages is l

SUBMITTER: Chu Z 

PROVIDER: S-EPMC7052205 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature