Dose-time fractionation schedules of preoperative radiotherapy and timing to surgery for rectal cancer.

ABSTRACT: Chemoradiotherapy (CRT) is extensively used prior to surgery for rectal cancer to provide significantly better local control, but the radiotherapy (RT), as the other component of CRT, has been subject to less interest than the drug component in recent years. With considerable developments in RT, the use of advanced techniques, such as intensity-modulated radiotherapy (IMRT) in rectal cancer, is garnering more attention nowadays. The radiation dose can be better conformed to the target volumes with possibilities for synchronous integrated boost without increased complications in normal tissue. Hopefully, both local recurrence and toxicities can be further reduced. Although those seem to be of interest, many issues remain unresolved. There is no international consensus regarding the radiatio

SUBMITTER: Jin F 

PROVIDER: S-EPMC7052459 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature