HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium.

ABSTRACT: Selenium is a trace element for most organisms; its deficiency and excess are detrimental. Selenium beneficial effects are mainly due to the role of the 21^st genetically encoded amino acid selenocysteine (Sec). Selenium also exerts Sec-independent beneficial effects. Its harmful effects are thought to be mainly due to non-specific incorporation in protein synthesis. Yet the selenium response in animals is poorly understood. In Caenorhabditis elegans, Sec is genetically incorporated into a single selenoprotein. Similar to mammals, a 20-fold excess of the optimal selenium requirement is harmful. Sodium selenite (Na₂SeO₃) excess causes development retardation, impaired growth, and neurodegeneration of motor neurons. To study the organismal response to s

SUBMITTER: Romanelli-Credrez L 

PROVIDER: S-EPMC7052493 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature