Rats genetically selected for low and high aerobic capacity exhibit altered soleus muscle myofilament functions.

ABSTRACT: Aerobic exercise capacity is critical to bodily health. As a model to investigate the mechanisms that determine health and disease, we employed low (LCR) and high (HCR) capacity running rat models selectively bred to concentrate the genes responsible for divergent aerobic running capacity. To investigate the skeletal muscle contribution to this innate difference in running capacity we employed an approach combining examination of the myofilament protein composition and contractile properties of the fast fiber extensor digitorum longus (EDL) and slow fiber soleus (SOL) muscles from LCR and HCR rats. Intact muscle force experiments demonstrate that SOL, but not EDL, muscles from LCR rats exhibit a three times greater decrease in fatigued force. To investigate the mechanism of this increased

SUBMITTER: Biesiadecki BJ 

PROVIDER: S-EPMC7052611 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature