Spinal cord injury alters purinergic neurotransmission to mesenteric arteries in rats.

ABSTRACT: Complications associated with spinal cord injury (SCI) result from unregulated reflexes below the lesion level. Understanding neurotransmission distal to the SCI could improve quality of life by mitigating complications. The long-term impact of SCI on neurovascular transmission is poorly understood, but reduced sympathetic activity below the site of SCI enhances arterial neurotransmission (1). We studied sympathetic neurovascular transmission using a rat model of long-term paraplegia (T2-3) and tetraplegia (C6-7). Sixteen weeks after SCI, T2-3 and C6-7 rats had lower blood pressure (BP) than sham rats (103  ±  2 and 97  ±  4 vs. 117  ±  6 mmHg, P < 0.05). T2-3 rats had tachycardia (410  ±  6 beats/min), and C6-7 rats had bradycardia (299  ±  10 beats/min) compared with intact rats (

SUBMITTER: Sangsiri S 

PROVIDER: S-EPMC7052627 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature