Flavored e-liquids increase cytoplasmic Ca²⁺ levels in airway epithelia.

ABSTRACT: E-cigarettes are noncombustible, electronic nicotine-delivery devices that aerosolize an e-liquid, i.e., nicotine, in a propylene glycol-vegetable glycerin vehicle that also contains flavors. While the effects of nicotine are relatively well understood, more information regarding the potential biological effects of the other e-liquid constituents is needed. This is a serious concern, because e-liquids are available in >7,000 distinct flavors. We previously demonstrated that many e-liquids affect cell growth/viability through an unknown mechanism. Since Ca²⁺ is a ubiquitous second messenger that regulates cell growth, we characterized the effects of e-liquids on cellular Ca²⁺ homeostasis. To better understand the extent of this effect, we screened e-liquids for their a

SUBMITTER: Rowell TR 

PROVIDER: S-EPMC7052665 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature