Mesenchymal stem/stromal cells-derived IL-6 promotes nasopharyngeal carcinoma growth and resistance to cisplatin via upregulating CD73 expression.

ABSTRACT: Previous studies have implicated the important role of mesenchymal stem/stromal cells (MSCs) within tumor microenvironment (TME) in the pathogenesis and progression of nasopharyngeal carcinoma (NPC), but the potential mechanisms are still unclear. Herein, we showed that an elevated IL-6 level was positively correlated with elevated expression of CD73 in TME of NPC. NPC specimens with an IL-6^highCD73^high phenotype showed higher expression levels of gp80, gp130, p-STAT3, MMP-9 and α-SMA, and clinically, a poorer prognosis than those with an IL-6^lowCD73^low phenotype. We found that stimulation with conditioned media derived from IL-6 gene knocked out MSC (MSC^IL6KO-CM) down-regulated the expression of CD73, IL-6, gp80, p-STAT3, and prolifer

SUBMITTER: Zeng J 

PROVIDER: S-EPMC7052921 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature