Weighted gene co-expression network analysis identified MYL9 and CNN1 are associated with recurrence in colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) is one of the most common carcinomas and the fourth leading cause of cancer-related death worldwide. One of the obstacles in the successful treatment of CRC is a high rate of recurrence. We aimed to construct weighted gene co-expression network analysis (WGCNA) to identify key modules and hub genes in association with recurrence in CRC patients. We firstly used the microarray data, GSE41258, to construct a co-expression network and identify gene modules. Furthermore, protein and protein interaction (PPI) network was also performed to screen hub genes. To validate the hub genes, an independent dataset GSE17536 was used for survival analyses. Additionally, another two databases were also performed to investigate the survival rates and expression levels of hub genes. G

SUBMITTER: Qiu X 

PROVIDER: S-EPMC7052925 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature