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Combination versus single-agent as palliative chemotherapy for gastric cancer.

ABSTRACT: BACKGROUND:Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting. METHODS:A retrospective review was conducted on 687 RPMGC patients who received palliative chemotherapy. We compared the overall survival (OS) between CC and single-agent chemotherapy (SC) among these patients, and we analyzed the clinicopathological characteristics affecting outcome including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). RESULTS:Although 521 patients (75.8%) underwent CC, SC was more frequently performed in elderly patients (57.6%) and ECOG performance status (PS) 2 or 3 (65.8%) patients (p?

SUBMITTER: Choi JH 

PROVIDER: S-EPMC7052983 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Combination versus single-agent as palliative chemotherapy for gastric cancer.

Choi Jin-Hyuk JH   Choi Yong Won YW   Kang Seok Yun SY   Jeong Geum Sook GS   Lee Hyun Woo HW   Jeong Seong Hyun SH   Park Joon Seong JS   Ahn Mi Sun MS   Sheen Seung Soo SS  

BMC cancer 20200302 1

<h4>Background</h4>Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting.<h4>Methods</h4>A retrospective review was conducted on 687 RPMGC patients who received palliative chemotherapy. We compared the overall survival (OS) between CC and single-agent chemotherapy (SC) among these patients, and we analyzed the clinicopathological characteristics affecting outcome including neutro  ...[more]