GenomeQC: a quality assessment tool for genome assemblies and gene structure annotations.

ABSTRACT: BACKGROUND:Genome assemblies are foundational for understanding the biology of a species. They provide a physical framework for mapping additional sequences, thereby enabling characterization of, for example, genomic diversity and differences in gene expression across individuals and tissue types. Quality metrics for genome assemblies gauge both the completeness and contiguity of an assembly and help provide confidence in downstream biological insights. To compare quality across multiple assemblies, a set of common metrics are typically calculated and then compared to one or more gold standard reference genomes. While several tools exist for calculating individual metrics, applications providing comprehensive evaluations of multiple assembly features are, perhaps surprisingly, lacking. Her

SUBMITTER: Manchanda N 

PROVIDER: S-EPMC7053122 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature