MUC1 is associated with TFF2 methylation in gastric cancer.

ABSTRACT:

Background

Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori-infected pathogenesis of gastric cancer (GC). A recent study revealed that H. pylori infection induced obviously increased Tff2 methylation levels in Muc1^-/- mice compared with controls. However, little is known of the molecular mechanism on MUC1 regulating the expression of TFF2.

Methods

We conducted a correlation analysis of MUC1 and TFF2 in public databases and our adjacent GC tissues. Besides, MUC1 overexpression vector or small interfering RNA (siRNA) was transfected into GC cells to assess the change in TFF2 expression. Furthermore, the methylation status of TFF2 was measured by bisulfite sequencing PCR (BSP).

Results

The expression of MUC1 was significantly

SUBMITTER: Ge Y 

PROVIDER: S-EPMC7053135 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature