Comprehensive proteomics investigation of P. vivax-infected human plasma and parasite isolates.

ABSTRACT: BACKGROUND:In recent times, Plasmodium vivax (P. vivax) has become a serious threat to public health due to its ability to cause severe infection with fatal outcomes. Its unique biology makes it resilient to control measures that are otherwise effective against P. falciparum. A deeper understanding of P. vivax biology and pathogenesis is, therefore, essential for developing the right control strategies. Proteomics of P. falciparum has been helpful in studying disease biology and elucidating molecular mechanisms involved in the development of disease. However, unlike P. falciparum, proteomics data for P. vivax infection is minimal due to the absence of a continuous culture system. The dependence on clinical samples and animal models has drastically limited P. vivax research, creating critic

SUBMITTER: Venkatesh A 

PROVIDER: S-EPMC7053139 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature