Combined elevation of TRIB2 and MAP3K1 indicates poor prognosis and chemoresistance to temozolomide in glioblastoma.

ABSTRACT:

Introduction

Glioblastoma (GBM) is the most lethal primary malignant brain tumor in adults with poor survival due to acquired therapeutic resistance and rapid recurrence. Currently, the standard clinical strategy for glioma includes maximum surgical resection, radiotherapy, and temozolomide (TMZ) chemotherapy; however, the median survival of patients with GBM remains poor despite these comprehensive therapies. Therefore, the identification of new prognostic biomarkers is urgently needed to evaluate the malignancy and long-term outcome of glioma.

Aims

To further investigate prognostic biomarkers and potential therapeutic targets for GBM.

Results

In this study, we identified tribbles pseudokinase 2 (TRIB2) as one of the genes that is most correlated with pathological cl

SUBMITTER: Wang J 

PROVIDER: S-EPMC7053231 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature