Preoperative Sedative-hypnotic Medication Use and Adverse Postoperative Outcomes.

ABSTRACT:

Objective

To determine the association between preoperative benzodiazepine and nonbenzodiazepine receptor agonist ("Z-drugs") use and adverse outcomes after surgery.

Background

Prescriptions for benzodiazepines and Z-drugs have increased over the past decade. Despite this, the association of preoperative benzodiazepines and Z-drug receipt with adverse outcomes after surgery is unknown.

Methods

Using the Optum Clinformatics Datamart, we performed a retrospective cohort study of adults 18 years or older who underwent any of 10 common surgical procedures between 2010 and 2015. The principal exposure was one or more filled prescriptions for a benzodiazepine or Z-drug in the 90 days before surgery. The primary outcome was any emergency department visit or hospital admissio

SUBMITTER: Gaulton TG 

PROVIDER: S-EPMC7053280 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature