Association between oral anticoagulants and osteoporosis: Real-world data mining using a multi-methodological approach.

ABSTRACT: Introduction: Warfarin and direct oral anticoagulants (DOACs) have been widely used in antithrombotic therapy. Although warfarin use has been suspected to be associated with osteoporosis risk, several studies have shown otherwise. Conversely, a few reports have found an association between DOACs and osteoporosis. This study therefore clarifies the association between oral anticoagulants and osteoporosis by analyzing real-world data using different methodologies, algorithms, and databases. Methods: Real-world data from the US Food and Drug Administration Adverse Event Reporting System (FAERS; 2004-2016) and Japanese administrative claims database (2005-2017; JMDC Inc., Tokyo) were used. Reporting odds ratio (ROR) and information component (IC) were calculated through dispropor

SUBMITTER: Yokoyama S 

PROVIDER: S-EPMC7053309 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature