Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury.

ABSTRACT: Carbon tetrachloride (CCl4), Concanavalin A (ConA), bile duct ligation (BDL), and liver resection (LR) are four types of commonly used mouse models of acute liver injury. However, these four models belong to different types of liver cell damage while their application situations are often confounded. In addition, the systematic changes of multiple extra-liver organs after acute liver injury and the crosstalk between liver and extra-liver organs remain unclear. Here, we aim to map the morphological, metabolomic and transcriptomic changes systematically after acute liver injury and search for the potential crosstalk between the liver and the extra-liver organs. Significant changes of transcriptome were observed in multiple extra-liver organs after different types of acute liver injury despit

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC7053327 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature