Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR.

ABSTRACT:

Background

It is generally thought that the occurrence and progression of osteoarthritis (OA) results from multiple causes, including degradation and destruction of the cartilage matrix and aging of chondrocytes. Metformin is a first-line drug for the treatment of diabetes, and has great potential for the treatment of other disorders. However, the role of metformin in OA is unknown.

Results

Metformin displayed a protective effect against OA. There were lower OARSI scores and fewer MMP-13-positive cells in DMM mice and cartilage explants after treatment with metformin. In addition, metformin treatment decreased p16^INK4a levels in OA chondrocytes, and enhanced polarization of AMPK and inhibition of mTORC1 in OA mice and chondrocytes in a dose-dependent manner.

Co

SUBMITTER: Feng X 

PROVIDER: S-EPMC7053618 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature