Epigenetic and parasitological parameters are modulated in EBi3-/- mice infected with Schistosoma mansoni.

ABSTRACT: Schistosoma mansoni adaptive success is related to regulation of replication, transcription and translation inside and outside the intermediate and definitive host. We hypothesize that S. mansoni alters its epigenetic state in response to the mammalian host immune system, reprogramming gene expression and altering the number of eggs. In response, a change in the DNA methylation profile of hepatocytes could occurs, modulating the extent of hepatic granuloma. To investigate this hypothesis, we used the EBi3-/- murine (Mus musculus) model of S. mansoni infection and evaluated changes in new and maintenance DNA methylation profiles in the liver after 55 days of infection. We evaluated expression of epigenetic genes and genes linked to histone deubiquitination in male and female S. mansoni worm

SUBMITTER: Mota EA 

PROVIDER: S-EPMC7053770 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature