Gut microbiota composition explains more variance in the host cardiometabolic risk than genetic ancestry.

ABSTRACT: Cardiometabolic affections greatly contribute to the global burden of disease. The susceptibility to obesity, cardiovascular disease, and type-2 diabetes, conditions that add to the cardiometabolic syndrome (CMS), was associated with the ancestral genetic composition and gut microbiota. Studies explicitly testing associations between genetic ancestry and gut microbes are growing. We here examined whether the host genetic ancestry was associated with gut microbiota composition, and distinguished the effects of genetic ancestry and non-genetic factors on human cardiometabolic health. We performed a cross-sectional study with 441 community-dwelling Colombian mestizos from five cities spanning the Andes, Pacific, and Caribbean coasts. We characterized the host genetic ancestry by genotyping 40

SUBMITTER: Guzman-Castaneda SJ 

PROVIDER: S-EPMC7053924 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature