Enhancers as regulators of antigen receptor loci three-dimensional chromatin structure.

ABSTRACT: Enhancers are defined as regulatory elements that control transcription in a cell-type and developmental stage-specific manner. They achieve this by physically interacting with their cognate gene promoters. Significantly, these interactions can occur through long genomic distances since enhancers may not be near their cognate promoters. The optimal coordination of enhancer-regulated transcription is essential for the function and identity of the cell. Although great efforts to fully understand the principles of this type of regulation are ongoing, other potential functions of the long-range chromatin interactions (LRCIs) involving enhancers are largely unexplored. We recently uncovered a new role for enhancer elements in determining the three-dimensional (3D) structure of the immunoglobuli

SUBMITTER: Barajas-Mora EM 

PROVIDER: S-EPMC7053977 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature