Ontology highlight
ABSTRACT:
SUBMITTER: Hathcock D
PROVIDER: S-EPMC7054003 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Hathcock David D Tehver Riina R Hinczewski Michael M Thirumalai D D
eLife 20200115
The molecular motor myosin V transports cargo by stepping on actin filaments, executing a random diffusive search for actin binding sites at each step. A recent experiment suggests that the joint between the myosin lever arms may not rotate freely, as assumed in earlier studies, but instead has a preferred angle giving rise to structurally constrained diffusion. We address this controversy through comprehensive analytical and numerical modeling of myosin V diffusion and stepping. When the joint ...[more]